Growth During the First Two Years Predicts Pre-School Height in Children Born With Very Low Birth Weight (VLBW): Results of a Study of 1,320 Children in Germany

Abstract

Children born with very low birth weight (VLBW) are at risk of impaired growth. We aimed to study VLBW survivors (90.8%) born in 1998/1999 in the state of Baden-Württemberg (n = 2103) for whom growth data were available up to age six. Classification as appropriate for gestational age (AGA) or small for gestational age (SGA) depended on size at birth. Models to predict height SDS at 5 y were developed using data for 1 yr (Model 1) and 2 yrs (Model 2). The data of 1320 (63%) children were available: SGA: n = 730, AGA: n = 590. At 6 yrs, 8.3% AGA and 13.4% SGA children were short (<-2.0 SDS). The following factors explained Ht SDS at 5 (and 6) yrs (order of importance): (a) Model 1 (n = 1033; R2 = 0.52; error: 0.84 SDS): 1st yr Ht SDS, mid-parental height (MPH) SDS, 1 yr weight SDS, birth weight SDS; (b) Model 2 (n = 991; R2 = 0.72; error: 0.65 SDS): 1st yr Ht SDS; change (2nd yr) in Ht and weight SDS; MPH SDS; 1st yr weight SDS; birth weight SDS. Thus, some AGA and SGA children born VLBW remain short and preventive strategies need to be developed for those at risk.