Abstract
Diabetes mellitus (DM) is a disease characterized by increased blood sugar levels, consisting of Diabetes Mellitus type I (DMT1) and Diabetes Mellitus type II (DMT2). Chronic increases in blood glucose levels will cause oxidative stress through the accumulation of Reactive Oxygen Species (ROS). Oxidative stress will induce the secretion of pro- and anti-inflammatory mediators, including Growth Differentiation Factor-15 (GDF-15). GDF-15 levels can be used to predict the risk and progression of DM disease. In exploring diabetes, several studies were carried out on experimental animal models of diabetes, both T1DM and 2DMT models. This research is an experimental study with a Pre and Post-Test Control Group Design approach using rat animals divided into four groups (I=Control group; II=Alloxan group; III=Streptozotocin group and IV=Streptozotocin and high fat diet group) with the aim of to see the levels of Growth Differentiation Factor-15 (GDF-15) in diabetic animal model. Based on this research, there was an increase in levels of Growth Differentiation Factor-15 (GDF-15) before and after diabetic animal model in the Streptozotocin group P value 0.010; and Streptozotocin with a High Fat Diet group with P value of 0.043 (significance value P < 0.05).
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