Abstract
Filamentous fungi and yeasts both undergo polar growth. In Saccharomyces cerevisiae, where the mechanisms for polar growth are well-understood, polarity requires three steps: establishment of cortical markers specifying the site of bud emergence; relaying the bud site information via the Cdc42 Rho GTPase module; and recruitment of the morphogenetic machinery needed to remodel the cell surface to the specified site. Comparison of the genomes of Aspergillus fumigatus, A. nidulans and A. oryzae with that of S. cerevisiae show that the cortical markers are absent or poorly conserved, while the RhoGTPase signaling module and the morphogenetic machinery are highly conserved in the aspergilli. Genetic approaches to polarity using A. nidulans polarity mutants with defects in germ tube emergence (swo mutants) or branching (ahb mutants) will also be discussed.
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