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Abstract
SummaryThe capacity of nine poikilothermic vertebrate cell lines, of fish, amphibian, and reptilian origin, to support replication of strain CVS rabies virus was determined. Two fish cell lines and two amphibian cell lines supported little or no rabies virus infection, while five reptilian cell lines tested varied from essentially unsusceptible (iguana cell line IgH2) to a high susceptibility (viper cell line VSW) comparable to that of mammalian cells. Rabies virus serially propagated in VSW cells became virtually apathogenic for adult mice by passage level 81, yet remained highly immunogenic. Rabies virus serially propagated in the gecko cell line GL1 became highly attenuated for adult mice by passage level 40, but also expressed reduced immunogenicity. In two separate experiments, virus passaged in GL1 cells also acquired a small-plaque character in early passage. Ibadan shrew virus and Lagos bat virus, viruses antigenically related to rabies virus, both replicated efficiently in cell line VSW, but only...
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