Abstract

The possibility of creating three-dimensional differentiated tissue-like assemblies by culturing cells in microgravity, either in space or on the ground, offers research opportunities that may lead to the generation of replacement organs for transplantation, and for studying multicellular responses in toxicology, radiation biology, tumorigenesis, and embryogenesis. Here, Brian Unsworth and Peter Lelkes review these opportunities, considering the practical and theoretical challenges of the microgravity environment.

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