Abstract
Growing Threat Increased Carbapenem-Resistance among Klebsiella pneumoniae; Antibiotic Susceptibility Pattern of Klebsiella pneumoniae in a Tertiary Care Hospital
Highlights
The worldwide increase in the occurrence of antimicrobial resistance (AMR) and prevalence of infections with multidrug-resistant (MDR) Gram negative Enterobacteriaceae has become a global health problem
Antibiotic susceptibility test results indicated that the resistance to tigecycline was lowest (0, 3%)
Determination of hospital antimicrobial resistance rates will be useful in developing antibiotic use policies of each hospital, in the treatment of causative agents, in selecting antibiotics according to antimicrobial susceptibility
Summary
The worldwide increase in the occurrence of antimicrobial resistance (AMR) and prevalence of infections with multidrug-resistant (MDR) Gram negative Enterobacteriaceae has become a global health problem. Antimicrobial resistance could be accelerated by the misuse of antibiotics in animals and humans, leading to restricted treatment options, poor clinical outcomes and increasing hospital costs [1, 2]. Colonization of Klebsiella pneumoniae has been reported to be associated with long-term hospitalization, previous operation history, intravenous and urinary catheter administration and overuse of antibiotics [5]. This appreciable efficiency of colonization, enhanced by acquired resistance to antibiotics, enables K. pneumoniae to persist and spread rapidly in health care settings [6]. Treatment options for infections with carbapenemase-producing Klebsiella pneumoniae strains are limited and associated with high mortality [7]. The aim of this study is to determine the resistance profiles of Klebsiella pneumoniae strains isolated from various clinical specimens
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