Abstract
Using the immunofixation isoelectric focusing method, Gc subtypes were examined in the samples with the Gc J phenotypes previously determined by immunoelectrophoresis, and it was found that theGc Js are subdivided into 4 different alleles. A population study in sera from 1,041 individuals confirmed the presence of the 4 variant alleles with the frequencies between 0.020 for the highest allele and 0.001 for the lowest one. The distribution of Gc subtypes in a Japanese population and a pedigree study from 18 families with the propositus of the variant are presented along with a description of the 2 other variants observed in the course of this study.
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