Group IVB Metallocene Polyesters Containing Camphoric Acid and Preliminary Cancer Cell Activity

Abstract

Polyesters were formed from the reaction of the salt of camphoric acid and Group IVB metallocene dichlorides employing the interfacial polycondensation process. The polyesters were formed in good yields with moderate chain lengths. FTIR shows bands characteristic of the presence of both reactants with new bands characteristic of the formation of the M-O and M-O(CO) linkage present. The polymers largely exist in a bridging geometry of the carbonyl-groups about the metal atom. NMR shows the presence of bands derived from both reactants. MALDI MS shows ion fragments to three units for the polymers with isotopic abundances characteristic of the presence of metal atoms in the ion fragment clusters. All of the polymers exhibit good ability to inhibit all of the tested cancer cell lines but the zironocene and hafnocene polymers exhibit especially good inhibition of the tested cancer cell lines that included two pancreatic cancer cell lines. They represent a potential new group of anticancer drugs.Polyesters were formed from camphoric acid and Group IVB metallocene dichlorides employing the interfacial polycondensation process. IR, NMR and MLADI MS results are consistent with the proposed structure. Polymers exhibit outstanding ability to inhibit the tested cancer cell lines including two pancreatic cancer cell lines. They represent a potential new group of anticancer drugs.