Abstract
Prostaglandin (PG) E 2 is considered to participate in the storage of fat in adipocytes and hepatocytes, but roles of group IVA phospholipase A 2 (PLA 2), a key PLA 2 isozyme in the arachidonic acid cascade, remain unclear. The present study examined the possible involvement of the enzyme using group IVA PLA 2-deficient mice (C57BL/6 background, 22 weeks of age) fed a normal diet (5.3% fat). The ratio of epididymal fat pad weight to body weight was significantly reduced in group IVA PLA 2-deficient mice compared to wild-type mice. Histological analysis revealed that in group IVA PLA 2-deficient mice, the adipocytes were smaller, and hepatocytes bearing cytoplasmic vacuolation were scarce. Hepatic triglyceride content and the serum levels of PGE 2 in the deficient mice were also lower. However, there was no difference in the serum levels of insulin, glucose, non-esterified free fatty acid, or total cholesterol between the deficient and wild-type mice. Our findings suggest that group IVA PLA 2 is involved in the storage of lipids in the adipose tissue and liver and in determining circulating PGE 2 levels.
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