Abstract
High-performance liquid chromatography retention data are reported for 2-phenylethylamine and 30 of its derivatives, including examples of CH3 OH, OCH3, COOH, NH2 and N-oxide substitution. An octadecyl-silica column was used with an eluent of 10% methanol containing an amine-phosphate buffer (pH 3.15) to limit the interference of the silica support with chromatographic retention. The effects of individual substituents on retention are quantified by using group-contribution values (τ) and are discussed with reference to the position of substitution and the intramolecular interactions with other groups.
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