Abstract
Innate lymphoid cells (ILCs) are vital innate immune cells cooperating with T cells. While their phenotypes and functions in oral mucosa kept unclear yet. In the present study, the relative proportions and distribution of different ILC subsets in oral mucosa of oral lichen planus (OLP), oral lichenoid lesions (OLL), and controls were compared. Oral mucosal samples were collected from control (n=29), OLP (n=20), and OLL (n=22) donors. ILCs subsets were characterized in single-cell suspensions by flow cytometry. Immunohistochemistry was performed to locate the CD127+ cells in situ. ILCs were present in healthy and increased infiltration in OLP/OLL (p=0.0092, p=0.0216). Infiltration of ILC1 increased in OLP/OLL mucosa (p=0.0225, p=0.0399), as did the infiltration of ILC3 increase in OLL mucosa (p=0.0128). The ILC2/ILCs ratio was significantly reduced in OLP and OLL (p=0.0124, p=0.0346). CD127+ cells were mainly located closely at the basement membrane. The results of increased ILC1, decreased ILC2, and increased ILC3 suggested that changes of ILC distributions in oral mucosa may be relevant to persistent inflammation in local tissues, by promoting immune factors and weakening repair capacity.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.