Abstract
Lichen Planus is a chronic immunologically mediated mucocutaneous disorder with varied clinical manifestations. The condition might be associated with multiple causative or exacerbation factors. An interesting association of Oral Lichen Planus with Diabetes Mellitus and vascular hypertension is called as Grinspan's syndrome. Since its inception has been an arena of interest. It has appeared very lucrative to many researchers as it lacks clarity and enhanced ambiguity. A 65 year female patient came with a complaint of burning mouth and difficulty in swallowing since 1 year with H/O Diabetes Mellitus since 8years and hypertension since 2 years. Malignant transformation is the most significant complication of long standing and non healing Lichen Planus. Repeated follow up and biopsies are mandatory for prevention and early detection of malignant transformation.
 Keywords: Grinspan Syndrome, Hypertrophic Lichen Planus, Esophageal Lichen Planus
Highlights
Lichen planus is a chronic immunologically mediated mucocutaneous disorder with varied clinical manifestations affecting the skin, oral mucosa, nail, genital mucosa, and the scalp
Based on the above features a clinical diagnosis of Hypertrophic Lichen Planus of the skin was rendered along with Grinspan Syndrome (Oral lichen Planus, Diabetes Mellitus and Hypertension) involving esophagus
Hypertrophic lichen planus generally develops during the course of a sub acute attack but infrequently only hypertrophic or warty lesions are found
Summary
Lichen planus is a chronic immunologically mediated mucocutaneous disorder with varied clinical manifestations affecting the skin, oral mucosa, nail, genital mucosa, and the scalp. The condition is T cell mediated, where the CD8+ T cells trigger the apoptosis of oral epithelial cells at the basal layer. It has a well established clinical features and histopathological features that aid in the diagnosis. On oral examination, showed pigmentation of lips and labial mucosa Buccal mucosa on both the sides showed dark pigments with focal areas of white striae. Based on the above features a clinical diagnosis of Hypertrophic Lichen Planus of the skin was rendered along with Grinspan Syndrome (Oral lichen Planus, Diabetes Mellitus and Hypertension) involving esophagus. Figure 6a: ( Right Buccal Mucosa) and 6b: ( Left Buccal Mucosa): Lesions involving both the sides of buccal mucosa with thin white striae. Figure 3a: ( Right Knee) and 3b: ( Left knee): Lesions with bleeding spots noted
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