Grinding the way to enantiopurification

Abstract

Inspired by the similarities between intermolecular recognition for chiral separation and the role of these same interactions in the solid state, in this issue of Chem, Puccetti et al. have identified a potentially transformative route for purifying enantiomers using a simple ball milling procedure. Inspired by the similarities between intermolecular recognition for chiral separation and the role of these same interactions in the solid state, in this issue of Chem, Puccetti et al. have identified a potentially transformative route for purifying enantiomers using a simple ball milling procedure. NMR in operando monitoring of mechanochemically accelerated sublimationsPuccetti et al.ChemMarch 24, 2023In BriefMethods for the monitoring of mechanochemical transformations are of fundamental importance for the understanding of property variations of the milled species. Here, the combination of mechanical grinding and NMR spectroscopy is utilized to accelerate and monitor the phenomena of self-disproportionation of enantiomers via sublimation of α-(trifluoromethyl)lactic acid. The concept of dependence of physicochemical properties on the interaction between chiral species is reapplied in the modulation of the sublimation rate of d-(+)-camphor through the introduction of chiral milling additives. Full-Text PDF