Abstract
AbstractThe effect of grinding on the physicochemical properties of ground mixtures of crystalline drugs (acetaminophen, warfarin, indomethacin, diazepam and hydrocortisone acetate) with 3-cyclodextrin was studied by IR analysis, x-ray diffraction method and thermal analysis. The crystallinities of drugs decreased with increasing grinding time and became amorphous or nearly amorphous, which depended on drug moiety and cavity size of 3-cyclodextrin. The result indicates that acetaminophen became amorphous and only formed an inclusion complex in the ground mixture with 3-cyclodextrin, although all five drugs interacted with 3-cyclodextrin in water. The dissolution rate of drugs from the ground mixtures was shown to be higher than that of the ground drug, crystalline drug or physical mixture, while the dissolution rate of the inclusion complex was the very highest. Physicochemical stability of the ground mixtures stored under 40°C and 75% RH condition was measured by differential scanning calorimetry. In the...
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
