Abstract
Pain management after surgery is one of the things in improving the condition of patients in veterinary and human medicine, which was controlled in small animals with drugs and systemic anti-inflammatory drugs. Analgesics were administered subcutaneously using the usual infiltration injection method in small animals before the start of surgery. In this study, post-anesthesia recovery and pain levels were investigated following the analgesia of subcutaneous injections after abdominal surgery with lidocaine and bupivacaine drugs and their combination. Lidocaine 0.1 and 0.15mg.kg-1 and bupivacaine 1 and 2mg.kg-1 and combination with doses of 0.1mg.kg-1 lidocaine and 1mg.kg-1 bupivacaine were used for this research. Also, the data of this study was evaluated using Rodent Face Finder software, which was one of the newest methods for evaluating pain during the recovery of animal models based on clinical changes. Clinical changes include ratings in eye-opening (Orbital changes), various ear angles (Ear changes), whisker stance (Whisker changes), and cheek angle (Cheek changes). The videos were taken at 0, 2, 4, 8, 12, and 24 hours from different groups have been analyzed by software and statistical evaluation data. The results obtained 2 hours after the surgery of the combined drug group (mixed drugs) have a significant difference compared to all groups (P<0.05), and the rest of the groups did not have a significant difference (P>0.05) due to the effects They are indifferent. Pain before anesthetics and anesthesia can be justified. At 4 and 8 hours, the lidocaine and bupivacaine groups are not significantly differentiated from each other (P>0.05), but the treatment groups are different from each other (P<0.05). At 12 hours, the lidocaine groups and the saline 0.09% group had significant differences (P<0.05), and the rest of the groups did not have differences (P>0.05). At 24 hours after surgery, only the control group has a significant difference from the other groups (P<0.05). The study showed that the combination of anesthetic drugs with the specified doses brings adequate analgesia in the first hours after surgery, and proper recovery is observed compared to other treatment groups. Also, different rates of postoperative analgesia at 4 and 8 hours after surgery have no significant effect on the process of analgesia. Anesthetic drugs can have a significant effect on the initial recovery process.
Published Version
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