Greener solid state synthesis of nano-sized mono and homo bi-nuclear Ni(II), Co(II), Mn(II), Hg(II), Cd(II) and Zn(II) complexes with new sulfa ligand as a potential antitumour and antimicrobial agents

Abstract

Abstract New nano-sized mono and homo bi-nuclear Ni(II), Co(II), Mn(II), Hg(II), Cd(II) and Zn(II) complexes with 4-[(2-hydroxybenzylidene)amino]- N -(1,3-thiazol-2-yl)benzenesulfonamide (H 2 L) were synthesized by solid-solid reaction at room temperature. The complexes were structurally characterized using MS, FT-IR, UV–Vis, ESR, 1 H and 13 C NMR, spectra, thermal analyses, X-ray powder diffraction, SEM, conductance and magnetic measurements. FT-IR and NMR studies denoted that H 2 L coordinates to the metallic centers in a di-basic tetra-dentate mode using both the Schiff base center and the sulfonamide part. UV–Vis, ESR spectra and thermo-gravimetric analysis revealed that whole complexes attain tetrahedral geometry. Coats-Redfern method was applied in calculating the activation thermo-kinetic parameters ( E* , ∆ H* , ∆ S* , and ∆ G* ) for the diverse thermal decomposition stages from TGA curves. The data obtained from XRD and SEM images unequivocally asserted the nano-sized metal chelates. The inspected structures were propped using 3-D molecular modeling of some complexes employing molecular mechanics (MM +) and semi-empirical molecular orbital calculations (PM3). The recently inspected compounds were scrutinized for antimicrobial activities towards assorted species of bacteria and fungi. Also, the anticancer efficiency versus human liver Carcinoma cell line ( HEPG2 ) was examined. The results are very promising for their enforcements in therapeutic uses.