Greener Pharmaceuticals

Abstract

Future Medicinal ChemistryVol. 1, No. 3 CommentaryGreener pharmaceuticalsJames H Clark, Simon W Breeden & Louise SummertonJames H Clark† Author for correspondenceGreen Chemistry Centre of Excellence, Department of Chemistry, University of York, UK. Search for more papers by this authorEmail the corresponding author at jhc1@york.ac.uk, Simon W BreedenGreen Chemistry Centre of Excellence, Department of Chemistry, University of York, UK. Search for more papers by this authorEmail the corresponding author at jhc1@york.ac.uk & Louise SummertonGreen Chemistry Centre of Excellence, Department of Chemistry, University of York, UK. Search for more papers by this authorEmail the corresponding author at jhc1@york.ac.ukPublished Online:29 Jun 2009https://doi.org/10.4155/fmc.09.46AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articlePapers of special note have been highlighted as: ▪ of interestBibliography1 Sheldon RA. The E factor 15 years on. Green Chem.9,1273–1283 (2007).▪ A large number of other metrics are available; an attempt to unify green metrics has been made by Andraos [12].Crossref, CAS, Google Scholar2 NHS SDU. NHS England carbon emissions: carbon footprinting emissions projections to 2020 – January. NHS Sustainable Development Unit, Cambridge, UK (2009).Google Scholar3 Dunn PJ, Galvin S, Hettenbach K. The development of an environmentally benign synthesis of sildenafil citrate (Viagra) and its assessment by green chemistry metrics. Green Chem.6,43–48 (2004).Crossref, CAS, Google Scholar4 Kuzemko MA, Van Arnum SD, Niemczyk HJ. A green chemistry comparative analysis of the syntheses of (E)-4-cyclobutyl-2-[2-(3-nitrophenyl)ethenyl] thiazole, Ro 24–5904. Org. Process Res. Dev.11(3),470–476 (2007).▪ First paper to refer to the sildenafil synthesis as the industry ‘gold standard’.Crossref, CAS, Google Scholar5 Constable DJC, Dunn PJ, Hayler JD et al. Key green chemistry research areas – a perspective from pharmaceutical manufacturers. Green Chem.9,411–420 (2007).Crossref, CAS, Google Scholar6 Comerford JW, Clark JH, Macquarrie DJ, Breeden SW. Clean, reusable and low cost heterogeneous catalyst for amide synthesis. Chem. Commun. (Camb.) DOI: 10.1039/B901581G (Epub ahead of print).Google Scholar7 Polshettiwar V, Varma RS. Nanoparticle-supported and magnetically recoverable ruthenium hydroxide catalyst: efficient hydration of nitriles to amides in aqueous medium. Chemistry15,1582–1586 (2009).Crossref, Medline, CAS, Google Scholar8 Polshettiwar V, Baruwati B, Varma RS. Magnetic nanoparticle-supported glutathione: a conceptually sustainable organocatalyst. Chem. Commun. (Camb.)1837–1839 (2009).Crossref, Medline, Google Scholar9 Anastas P, Warner J. Green Chemistry: Theory and Practice. Oxford University Press, NY, USA (1998).Google Scholar10 Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Del. Rev.46,3–26 (2001).Crossref, Medline, CAS, Google Scholar11 NHS SDU. (2009) NHS carbon reduction Strategy for England: key actions. NHS Sustainable Development Unit, Cambridge, UK (2009).Google Scholar12 Andraos J. Unification of reaction metrics for green chemistry II: evaluation of named organic reactions and application to reaction discovery. Org. Process Res. Dev.9,404–431 (2005).▪ A large number of metrics are available, with Andraos providing an attempt to unify green metrics.Crossref, CAS, Google Scholar101 Janusinfo: environment and pharmaceuticals. www.janusinfo.se/imcms/GetDoc?meta_id=7241Google ScholarFiguresReferencesRelatedDetailsCited ByThe role of solvent selection at exploratory and production stages in the pharmaceutical industryDaniel R Nicponski & P Veeraraghavan Ramachandran1 September 2011 | Future Medicinal Chemistry, Vol. 3, No. 12 Vol. 1, No. 3 Follow us on social media for the latest updates Metrics Downloaded 114 times History Published online 29 June 2009 Published in print June 2009 Information© Future Science LtdFinancial & competing interests disclosureThe authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.No writing assistance was utilized in the production of this manuscript.PDF download