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Abstract
The present study shows the neuroprotective effect of green tea supplementation (GT; Camellia sinensis) in a model of Intracerebral Hemorrhage (ICH) in rats. ICH was induced by intra-striatum collagenase infusion in male Wistar rats. GT (400 mg Kg-1) was administered via gavage for 10 days after ICH. We assessed the effect of GT on neuromotor recovery and oxidative damage. Our results show that ICH causes neuromotor deficits observed by Neurological Deficit Scale (NDS), Open Field (OF) and Rotarod (RR). GT treatment attenuates this deficit on day 3 for NDS and OF and on day 7 for RR. Also, ICH increases Reactive Oxygen Species (ROS) production and lipid peroxidation, what is not observed in ICH + GT group. Currently, there are no effective pharmacologic or non-pharmacologic neuroprotective treatments for ICH. Nutritional interventions that help on its outcome are important, since they are generally accessible and have few side effects.
Highlights
Hemorrhagic stroke caused by spontaneous Intracerebral Hemorrhage (ICH) represents 15 to 20% of all strokes (Flower and Smith, 2011)
Green tea effects were assessed in Neurological Deficit Scale (NDS), Open Field (OF) and RR behavioral tasks
Two-way ANOVA showed that ICH induced neuromotor deficit on days 1 (F(1,37) = 43.61; P = 0.0001), 3 (F(1,37) = 26.48; P
Summary
Hemorrhagic stroke caused by spontaneous ICH represents 15 to 20% of all strokes (Flower and Smith, 2011). ICH is the more severe type of stroke and has serious development (Hwang et al, 2011). Most patients either die or are left with significant neurological morbidity (Flower and Smith, 2011). The primary damage caused by ICH starts soon after the bleeding onset and is mainly due to hematoma formation, which compresses the surrounding brain tissue, destroying it (Xi et al, 2006). The progressive brain tissue deterioration suggests that secondary brain damage after ICH plays a fundamental role in neurological impairment (Babu et al, 2012), even without any signs of hematoma expansion
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