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Abstract
Green tea 1 Demeule M Michaud-Levesque J Annabi B et al. Green tea catechins as novel antitumor and antiangiogenic compounds. Curr Med Chem Anti-Canc Agents. 2002; 2: 441-463 Crossref PubMed Scopus (127) Google Scholar has always been considered by the Chinese and Japanese peoples as a potent medicine for the maintenance of health, endowed with the power to prolong life. Recently, Yean Lee and colleagues 2 Lee YK Bone ND Strege AK Jelinek DF Kay NE VEGF receptor phosphorylation status and apoptosis is modulated by a green tea component, epigallocatechin-3-gallate (EGCG) in B cell chronic lymphocytic leukemia. Blood. 2004; 104: 788-794 Crossref PubMed Scopus (193) Google Scholar looked at the effects of the main active green tea constituent, epigallocatechin-3-gallate (EGCG) on chronic lymphocytic leukaemia B cells isolated from leukaemic patients. These cells are characterised by their resistance to apoptosis because they secrete and bind vascular endothelial growth factor (VEGF), a potent angiogenic cytokine that also acts as a crucial survival factor for tumour cells. The researchers showed that addition of EGCG to these cells markedly decreased VEGF-receptor phosphorylation, leading to the disruption of the VEGF-dependent autocrine pathway that protects the cells from apoptosis and cell death.
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