Abstract
BackgroundDiastolic dysfunction refers to an impaired relaxation and an abnormality in a heart’s filling during diastole while left ventricular systolic function is preserved. Diastolic dysfunction is commonly observed in patients with primary hypertension, diabetes and cardiomyopathies such as hypertrophic cardiomyopathy or restrictive cardiomyopathy. We have generated a restrictive cardiomyopathy (RCM) mouse model with troponin mutations in the heart to mimic the human RCM patients carrying the same mutations.ResultsIn the present study, we have investigated the ventricular muscle internal dynamics and pressure developed during systole and diastole by inserting a micro-catheter into the left ventricle of the RCM mice with or without treatment of desensitizer green tea extracts catechins. Our results demonstrate that green tea catechin is able to correct diastolic dysfunction in RCM mainly by improving ventricular compliance and reducing the internal muscle rigidity caused by myofibril hypersensitivity to Ca2+.ConclusionGreen tea extract catechin is effective in correcting diastolic dysfunction and improving ventricular muscle intrinsic compliance in RCM caused by troponin mutations.
Highlights
Diastolic dysfunction refers to an impaired relaxation and an abnormality in a heart’s filling during diastole while left ventricular systolic function is preserved
We have demonstrated that hypersensitivity of myofibrils to Ca2+ is a key factor associated with impaired relaxation in the heart [9, 10]
In applying green tea extracts catechins into restrictive cardiomyopathy (RCM) mice, we have further indicated that Ca2+ desensitizer green tea catechins can reverse diastolic dysfunction in RCM mice with troponin mutations [13]
Summary
Diastolic dysfunction refers to an impaired relaxation and an abnormality in a heart’s filling during diastole while left ventricular systolic function is preserved. Diastolic dysfunction is commonly observed in patients with primary hypertension, diabetes and cardiomyopathies such as hypertrophic cardiomyopathy or restrictive cardiomyopathy. Diastolic dysfunction is a common sign in elderly population and in patients suffering from primary hypertension and various cardiomyopathies [1, 2]. Both hypertrophic cardiomyopathy (HCM) and restrictive cardiomyopathy (RCM) share a common feature of diastolic dysfunction [3, 4]. There is a critical need to understand the mechanisms that cause diastolic dysfunction and heart failure and to develop target-based intervention and medications to correct the overt condition and to treat the patients. In the absence of such agents and intervention, treatment of diastolic dysfunction is difficult and often ineffective [8]
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