Green tea consumption reduces apelin and orexin-A in overweight and obese women with different training modalities

Abstract

The purpose of this study was to investigate the effects of green tea (GT) consumption combined with different training modalities on orexin-A and apelin in overweight and obese women, and then to explore the relationship between apelin, orexin-A and body composition changes in response to training protocols. Forty-eight obese women participated in the study and were randomly assigned to one of four groups: aerobic training group, resistance training group, combined training group, and control group (3 days a week for 10 weeks). All groups ingested the same dose of GT. Blood samples were collected to analyze fasting glucose, insulin resistance, apelin and orexin-A concentrations. Insulin resistance was measured by homeostasis model assessment of insulin resistance index (HOMA-IR). Blood samples were collected before each exercise training and 24 h after of the last session. Orexin-A and apelin were decreased significantly after all exercise training modalities, whereas no changes in response to control group. Aerobic group showed greater reduction of blood samples than resistance and combined group. No benefit of GT supplementation only (Control group) on apelin and orexin-A was observed. In addition, Correlation was found between apelin and orexin-A after exercise training. All training modalities cause a reduction in insulin resistance, HOMA-IR, orexin-A and apelin in obese women. 10 weeks of aerobic exercise cause greater decreases in apelin and orexin-A than resistance and combined exercise trainings. In addition, the decrease in plasma apelin levels may contribute to reduction in orexin-A levels.