Abstract
In this current study, we demonstrated the green synthesis and characterization of silver nanoparticles using Myrtus communis L. plant extract (Ag-MC) and its evaluation of anticancer and antimicrobial activities. The green synthesis of (Ag-MC), was assessed by numerous characterization techniques such as ultraviolet-visible spectroscopy (UV-VIS), Fourier-transform infrared spectroscopy (FT-IR), X-ray powder diffraction (XRD) transmission electron microscopy (TEM) and energy dispersive x-ray spectroscopy (EDX). The anti-cancer activity of the green synthesized silver nanoparticles was evaluated by the median inhibitory dose (IC50) on human liver carcinoma cell lines (HepG2). These results suggested that SN-NPs can be used as effective anticancer cell lines, as well as antibacterial and antiseptic agents in the medical field. This study showed that overexpression of aldose reductase (AR) in the human liver carcinoma cell line, HepG2, was down regulated by administration of SN-MC. The down regulation of AR was associated with abrogation of Pl3k/Akt, ERK and NF-kB pathways and the inhibition of cancer hallmarks, however, the target molecule for Ag-MC was not practically established. Thus it is still unknown if the consequences were due to AR inhibition or direct Ag-MC interaction with AR.
Highlights
The size and morphology of synthesized metallic nanoparticles can be controlled with chemical reducing agents [1,2,3]
The present study summarizes green synthesis of silver nanoparticles using Myrtus communis L. plant extract (Ag-MC) and its anticancer effect on human liver carcinoma cell lines (HepG2), and determines the molecular mechanism underlying the modulatory effects of SN-MC on key molecules involved in survival signaling
The UV-Vis analysis of the green synthesized Ag-MC clearly reflected the sharp intensities of the absorption band at ~420 nm
Summary
The size and morphology of synthesized metallic nanoparticles can be controlled with chemical reducing agents [1,2,3]. The reducing agents and solvents used in the synthesis of nanoparticles are hazardous or toxic to the environment [2]. The green synthesis of nanoparticles is anticipated, even though there are a several categories of green reductants (based on isolation/extraction sources) existing in nature. Under these circumstances, green chemistry approaches can significantly assist with the preparations of metal nanoparticles [2]. Metal nanoparticles synthesis using plant extracts has been given more attention due to plants being available, inexpensive, environmentally friendly and the ability to highly reduce the usage of toxic solvents or reducing agents [9,10,11]
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