Abstract
In this study, Polyvinyl alcohol/Starch (PVA/Starch) cryogel scaffolds were combined with antibacterial silver nanoparticles (AgNPs), and the antimicrobial properties of composite scaffolds were determined for potential in tissue engineering applications. The porous PVA/Starch scaffolds were prepared by cryogelation technique. The nanoparticles were prepared by green synthesis from Aloe barbadensis leaf extract and characterized. The antibacterial, antifungal and antiyeast properties of AgNPs and AgNPs loaded PVA/Starch cryogel scaffolds were investigated. The highest antimicrobial activity of composite scaffold was found against Pseudomonas aeruginosa. Based on our studies, the results indicate that biodegradable, biocompatible and antimicrobial AgNPs loaded PVA/Starch scaffolds have potential to be used at an infection site in tissue engineering applications.
Highlights
Over the past few decades, green process for the synthesis of nanoparticles has attracted wide interest because of its inherent features such as rapidity, simplicity, being ecofriendly and cheap [1]
AgNPs were synthesized using Aloe barbadensis leaf extract as a reducing agent according to the method described in the previous section
Synthesis of AgNPs was proven with a color change from yellow to deep brown after 48 h of the addition of Aloe barbadensis leaf extract to silver nitrate solution
Summary
Over the past few decades, green process for the synthesis of nanoparticles has attracted wide interest because of its inherent features such as rapidity, simplicity, being ecofriendly and cheap [1]. A wide variety of applications include the use of nanoparticles due to their unique optical, electrical, mechanical, magnetic and chemical properties [2,3,4]. Due to their unique properties, metal nanoparticles, such as Ag, Au, Pt and Pd, are extensively used in pharmaceutical industry, clothing, cosmetics, optics, catalysis, mirrors, photography, electronics, food industry, and many other fields [5, 6]. One of the green methods of nanoparticle synthesis is the utilization of various plants and their parts [1]. Various plants have been used to synthesize silver nanoparticles, such as Azadirachta indica, Delonix elata, Tephrosia purpurea, Melia dubia, Tribulus terrestris, Artemisia nilagirica, Boerhaavia diffusa, Ficus religiosa, Piper pedicellatum and Melia azedarach [1, 8]
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