Green synthesis of ZnO nanoparticles using the leaf extract of Lavandula angustifolia and evaluation of their antibacterial activity against human pathogens

Abstract

The present study was aimed to the biosynthesis of Zinc oxide nanoparticles using leaf extract of Lavandula angustifolia. The nanoparticles were characterized by different techniques like UV-Visible spectroscopy, FESEM analysis, and X-ray diffraction. From the UV-Visible spectra analysis, it was observed the peak obtained at 350 nm confirmed the biosynthesis of LA-ZnONPs. The shape and size of LA-ZnONPs were confirmed by FESEM analysis, and from FESEM analysis it was found that the LA-ZnONPs were truncated and triangular in shape with an average size of 61.52 nm respectively. Further, the XRD analysis showed the LA-ZnONPs were crystalline in nature. By using well diffusion assay, the antibacterial activity of LA-ZnONPs was investigated against gram-positive S. aureus (ATCC 25923) and gram-negative E. coli (ATCC 11229) pathogens in a dose-dependent manner. The LA-ZnONPs exhibited excellent antibacterial activity against both the pathogens. The LA-ZnONPs thus possessed excellent antibacterial activity against human pathogens and can be used in drug development