Green synthesis of zinc oxide nanoparticles using the plant extract of Myristica fragrans and their antibacterial activity assessment

Abstract

BACKGROUND: Zinc nanoparticles (Zn-NPs) are useful for targeting specific tissues and pathogenic bacteria, which has attracted many researchers to their green manufacture and applications.METHODS: In the current study, Myristica fragrans aqueous seed extracts were used to synthesize zinc oxide nanoparticles (ZnO-NPs). Solution combustion synthesis (SCS) was used to generate useful zinc oxide nanoparticles (ZnO-NPs). Different methods were used to characterize the ZnO-NPs, including X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), elemental dispersion analysis of X-rays (EDX) and Transmission electron microscopy (TEM). Viable cell count and the broth-based turbidometry method were used to assess the antibacterial efficacy of green synthesized ZnO-NPs against three Gram-negative and two Gram-positive pathogens.RESULTS: The results of both the assay showed that the Zn nanoparticle from M. fragrans has significant highest antibacterial activity against P. aeruginosa and B. subtilis.CONCLUSIONS: As a result, the study suggests that Zn-NPs have potent antibacterial action and could be developed as a new class of antimicrobial drugs for the treatment of infections, particularly those that are resistant to several drugs.