Abstract
The production of eco-friendly nanoparticles with biocompatible properties is gaining prominence in global medical research. In this study, we explore the antibiofilm potential of Titanium dioxide nanoparticles (TiO2NPs) synthesized from Terminalia chebula against the oral pathogen Streptococcus mutans. Characterization of TiO2NPs revealed a UV–Vis peak at 322 nm. FT-IR spectrum identified Ti–O–Ti vibrations, hydroxyl, and carboxylic groups. SEM analysis revealed tetragonal TiO2NPs, with EDX confirming titanium. XRD confirmed TiO2 anatase crystallographic planes at 25.8° with an average grain size of the particle of 56 nm. Biofilm inhibitory activity indicated significant inhibition of biofilm with BIC50 of 65.71 μg/ml. Microscopic visualization substantiated the efficiency of TiO2NPs in impeding biofilm formation. Increased TiO2NPs concentrations showed a marked reduction in exopolysaccharide and increased protein leakage from S. mutans after prolonged exposure. These findings suggest TiO2NPs as potential agents for treating dental caries, though further validation is needed for therapeutic use in oral care.
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