Abstract
Silver nanoparticles in the form of silver based chemicals trace back their origin to time immemorial since the dilute forms of silver nitrate were used in place of antibiotics before they dominated the field of medicine. But, it has now become necessary to explore the anti-microbial properties of silver based chemicals again due to the microbes gaining resistance against the wide range of present day antibiotics. The advancements in the field of medicine and technology started to coalesce to combat the adaptability of microbes as they successfully become tolerant to antibiotics and it manifested in the form a current technology, Nanomedicine. Nanomedicine deals about the medicines at a nano scale to rarefy the intensity of medicine to unaffected tissues and reduce the volume of medicine used. In the present context, our attempt is to develop potential anti-microbial particles in the form of silver nanoparticles by using the biological phenomena which we call Green synthesis an eco-friendly approach to conventional chemical synthesis. The enzymatic machinery of the olive seeds has been exploited to produce silver nanoparticles and test their efficacy as antifungal agents before we characterized their physical properties using UV-Vis, TEM, and FTIR analysis. The efficacy of these particles as antagonists on fungal pathogen Aspergillus niger a causative agent of Aspergillosis in human beings and is promising and they have a lot of scope for the purpose and hope the technology leads the next generation of anti-microbials.
Highlights
Nanotechnology is one of the most interesting and open inquisitive fields for research in modern material science
Living systems are bequeathed with several chemical principles and the biomimetic approach of utilizing them could be a best alternative significantly reducing the usage of chemical reagents
The present study demonstrates the ecofriendly nature of the synthesis of silver nanoparticles at a rate on par with
Summary
Nanotechnology is one of the most interesting and open inquisitive fields for research in modern material science. Various chemical methods have been replaced by biological for the synthesis of silver nanoparticles [1,2]. The natural products such as monosaccharide or plant extracts have been used as reducing agents during these studies. Microbiological methods are much slower than plant extracts and other chemical reducing agents for production of nanoparticles as observed from many studies. 2003 [5], Kumar and Munsted [6] suggested that the antimicrobial activity of Ag may be due to the binding of the Ag+ cation to electron donor groups in biological molecules containing sulfur, oxygen or nitrogen (e.g. enzymes) which, in turn, results in the loss of their function. UV-Vis spectral analyses, Transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR) analysis was used to characterize the silver nanoparticles formed
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