Abstract
In this study, benzaldehyde was reacted with benzoin condensation, oxidation and cyclization reaction to product phenytoin sodium under the supersonic wave radiation. In the condensation reaction, non-toxic vitamin B1 was used as a reactor instead of highly toxic cyanide on pH=9 at 70 oC. After that, FeCl3 • 6H2O was used as oxidant instead of concentrated nitric acid under the mild conditions. The results were that the yield of phenytoin sodium was up to 56.8%. There were many advantages in this improved synthesis method such as shorter reaction time, higher product purity, lower environmental pollution and higher product yield.
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