Green Synthesis of Novel Imidazoles Derivatives and Evaluation of Anticancer and Anthelmintic Activity

Abstract

The imidazole derivatives are nitrogen-containing heterocyclic rings and produce significant various pharmacological activity like anticancer, antitubercular, antifungal, anti-inflammatory, antiviral, antidepressant, antileishmanial activity and many more. The present study was planned to synthesize novel imidazoles and assess them as their anticancer and anthelmintic activity. To make an equivalent Schiff's base, sulfanilamide was first condensed with heteryl aldehydes. Using silica gel as a solid support, the Schiff's base was further treated with NH4OAC and acetylated/benzoylated isatin, yielding matching imidazoles. A comparison of the created microwave approach with the conventional method is discussed in this work. The physical and analytical data of synthesized compounds were studied, and were evaluated for their anticancer and anthelmintic activity. The findings demonstrated significant anticancer and anthelmintic activity of novel synthesized imidazoles compounds (1b – 8b). The synthesized imidazoles possessed significant cytotoxic activity against Hep-2 cell line. The findings suggested the microwave method was more appropriate for the synthesis of imidazoles compounds (1b – 8b).