Abstract
Green synthesizes of silver nanoparticles is a promising method in material science and nanotechnology today. Silver nanoparticles (AgNP) were synthesized using a high-efficiency, cost-effective green and simple method at room temperature using Solanum nigrum leaves extract. The biosynthesized AgNP was validated and classified using spectroscopy profiles from ultraviolet-visible spectroscopy, scanning electron microscope, Fourier-transform infrared spectroscopy and x-ray diffraction. FTIR spectra indicated the presence of biological molecules in AgNP synthesis and UV-visible spectra revealed a surface resonance peak of 420 nm corresponding to AgNP formation. The antimicrobial potential of these synthesized nanoparticles is evaluated against the bacteria Escherichia coli (MCC 2079) and Staphylococcus aureus (MCC 2408), both of which are important foodborne pathogens. Ciprofloxacin and Clotrimazole were used as positive controls antibiotic. The nanoparticles were shown to have strong antibacterial efficacy against the strains examined. Their antibacterial function allows them to be included in antimicrobial formulations. By using the MTT assay, the biocompatibility of Solanum nigrum silver nanoparticles were found non-toxic to mouse fibroblast cell lines (L929 is one of the first in continuous culture to be created. The L strain was generated from a male C3H mouse's usual subcutaneous areolar and adipose tissue.) at lower concentrations.
Highlights
Nanotechnology is an interdisciplinary field of study that combines fundamental techniques from a variety of disciplines, including chemistry, engineering, physics, and biology, in order to create novel methods for manipulating and producing nanoparticles (NPS) [1, 2, 3]
The use of Solanum nigrum leaves extract as an effective reducing and capping agent resulted in an efficient, rapid, and green synthesis of AgNP in this research
Temperature, AgNO3 concentration, stirring conditions and time were all investigated as factors influencing AgNP synthesis
Summary
Nanotechnology is an interdisciplinary field of study that combines fundamental techniques from a variety of disciplines, including chemistry, engineering, physics, and biology, in order to create novel methods for manipulating and producing nanoparticles (NPS) [1, 2, 3]. Despite the fact that these methods are not ecologically friendly, noble metals such as gold, silver, platinum, and others are routinely utilized in the creation of nanoparticles utilizing a mixture of chemical and physical techniques. Microorganisms, spores, and plant extracts, among other biological processes, are increasingly often utilized in green biosynthesis approaches for the creation of nanoparticles. Silver nanoparticles (AgNP) have been shown to have important biological functions in treatments [4, 5, 6, 7]. The goal of this study was to explore into the usage of plant extracts in the green synthesis of AgNP. The plant has been used as a medicine for thousands of years, going back to ancient Greece.
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