Abstract
We report the synthesis of MnO nanoparticles (AI-MnO NAPs) using biological molecules of Abutilon indicum leaf extract. Further, they were evaluated for antibacterial and cytotoxicity activity against different pathogenic microbes (Escherichia coli, Bordetella bronchiseptica, Staphylococcus aureus, and Bacillus subtilis) and HeLa cancerous cells. Synthesized NAPs were also investigated for photocatalytic dye degradation potential against methylene blue (MB), and adsorption activity against Cr(VI) was also determined. Results from Scanning electron microscope (SEM), X-ray powder diffraction (XRD), Energy-dispersive X-ray (EDX), and Fourier-transform infrared spectroscopy (FTIR) confirmed the successful synthesis of NAPs with spherical morphology and crystalline nature. Biological activity results demonstrated that synthesized AI-MnO NAPs exhibited significant antibacterial and cytotoxicity propensities against pathogenic microbes and cancerous cells, respectively, compared with plant extract. Moreover, synthesized AI-MnO NAPs demonstrated the comparable biological activities results to standard drugs. These excellent biological activities results are attributed to the existence of the plant’s biological molecules on their surfaces and small particle size (synergetic effect). Synthesized NAPs displayed better MB-photocatalyzing properties under sunlight than an ultraviolet lamp. The Cr(VI) adsorption result showed that synthesized NAPs efficiently adsorbed more Cr(VI) at higher acidic pH than at basic pH. Hence, the current findings suggest that Abutilon indicum is a valuable source for tailoring the potential of NAPs toward various enhanced biological, photocatalytic, and adsorption activities. Consequently, the plant’s biological molecule-mediated synthesized AI-MnO NAPs could be excellent contenders for future therapeutic applications.
Highlights
Bacterial infections are still a major cause of fatalities over the globe
It has been perceived from the X-ray powder diffraction (XRD) pattern that no peak associated with impurity was detected, which displayed that the synthesized AI-MnO NAPs are pure
In this work, we have successfully synthesized AI-MnO NAPs functionalized with biologically active phytomolecules of hydroalcoholic leaf extract of A. indicum for the first time via a robust, economic, and eco-friendly approach
Summary
Bacterial infections are still a major cause of fatalities over the globe. The rapid emergence of resistance to multiple drugs in different bacteria have further made the condition more problematic. The development of simple, robust, efficient methods based on a photocatalyst system has attained enormous attention to disintegrate such synthetic dyes into less-toxic chemical waste In this instance, metal (Ag, Au, Pt, Cu, Zn, etc.) and their metal oxide (MgO, NiO, CuO, ZnO, TiO2, etc.) nanoparticles (NAPs) are considered as the most viable opportunity due to their unique physical characteristics, including the large surface area to volume ratio, controlled morphology (uniform and homogeneous), smaller size, and light-absorbing properties [5,6,7,8,9,10,11,12,13,14]. SScchheemmaattiicc pprreesseennttaattion ffoorr tthhee ggrreeeenn ssyynntthheessiiss ooff AAII--MMnnOO nnaannooppaarticles ((NAPs) using bbioiolologgicicaal lmmooleleccuulelessooffAAbbuutitliolonnininddicicuummleleaaffeexxttrraacctt
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