Abstract
The biological synthesis of nanoparticles, due to their environmental and biomedical properties, has been of particular interest to scientists and physicians. Here, iron nanoparticles (FeNPs) were synthesized using Satureja hortensis essential oil. Then, the chemical, functional, and morphological properties of these nanoparticles were characterized by typical experiments such as Uv-Vis, FTIR, XRD, FE-SEM, PSA, zeta potential, EDX, and EDX mapping. The results indicated Fe nanoparticles' formation with a cubic morphological structure and a particle size in the range of 9.3-27 nm. The antimicrobial effects of these nanoparticles were further evaluated using disc diffusion, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and minimum fungal concentration (MFC) against two gram-positive bacterial strains (Staphylococcus aureus and Corynebacterium glutamicum), two gram-negative bacterial strains (Pseudomonas aeruginosa and Escherichia coli), and one fungus species Candida albicans. The results showed that green-synthesized Fe nanoparticles possessed higher antimicrobial properties than Satureja hortensis essential oil against selected pathogenic microorganisms, especially Gram-negative bacteria. Finally, the anticancer effect of these Fe nanoparticles was investigated on human cancer cells, K-562, and MCF-7, by the MTT assay. The results showed the anticancer effect of these nanoparticles against selected cell lines.
Highlights
The desire to produce and use of nanometer dimensions is increasing due to the interesting industrial characteristics of these materials and their wide range of applications in various fields of biology, drugs, and medicine [1,2,3]
A relatively different and straightforward method for the first time was used for the synthesis of green iron magnetic NPs using the essential oil of the Satureja hortensis plant
The antibacterial effect of the FeNPs was investigated on five microbial strains, including two G+ bacteria, two G- bacteria, and a fungal species
Summary
The desire to produce and use of nanometer dimensions is increasing due to the interesting industrial characteristics of these materials and their wide range of applications in various fields of biology, drugs, and medicine [1,2,3]. Diseases of microbial and fungal origin are among the most well-known diseases that have always plagued humans, and numerous studies have been conducted to identify, control, and treat these pathogens [13,14,15]. Bacteria strains, such as Staphylococcus aureus, Escherichia coli, Streptococcus pyogenes, and Pseudomonas aeruginosa, as well as Candida albicans, are among the pathogens that cause many problems in human’s life [13,14,15]. Due to the genetic diversity of microbial pathogens, the emergence of resistant strains, and the side effects of these drugs, the replacement of chemical drugs with antimicrobial drugs of living origins such as plants, algae, bacteria, and fungi is incredibly important
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