Abstract
In this work, we have reported the biogenic supported silver nanoparticles over surface of magnetic Fe3O4 nanoparticles by using Pomegranate peel extract. The extract was used as a green reducing agent and an excellent stabilizer of the synthesized Ag NPs. Physicochemical characterization of the as-synthesized Fe3O4/Ag NPs was carried out through electron microscopy (SEM and TEM), energy dispersive X-ray spectroscopy (EDX), elemental mapping (WDX), vibrating sample magnetometer (VSM), X-ray diffraction (XRD) and inductively coupled plasma-optical emission spectroscopy (ICP-OES). Theanti-ovarian cancer effects of biologically synthesized Fe3O4/Ag NPs against ovarian cancer cell lines were assessed. The anti-ovarian cancer properties of the Fe3O4/Ag NPs could significantly remove NIH: OVCAR-3, ES-2, TOV-21G cancer cell lines in a time and concentration-dependent manner by MTT assay. The antioxidant activity of Fe3O4/Ag NPs was determined by DPPH method. The Fe3O4/Ag NPs showed the high antioxidant activity according to the IC50 value. It seems that the anti-human ovarian cancer effect of recent nanoparticles is due to their antioxidant effects. After clinical study, Fe3O4/Ag NPs bio-composite can be utilized as an efficient drug in the treatment of human ovarian cancer in humans.
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