Abstract
The in situ formation of silver nanoparticles (AgNPs) aided by chondroitin sulfate and the preparation of a hierarchically structured silver-polymer nanocomposite with antimicrobial activity is shown. Green synthesis of AgNPs is carried out by thermal treatment (80 and 90 °C) or UV irradiation of a chondroitin sulfate solution containing AgNO3 without using any further reducing agents or stabilizers. Best control of the AgNPs size and polydispersity was achieved by UV irradiation. The ice-segregation-induced self-assembly (ISISA) process, in which the polymer solution containing the AgNPs is frozen unidirectionally, and successively freeze-drying were employed to produce the chondroitin sulfate 3D scaffolds. The scaffolds were further crosslinked with hexamethylene diisocyanate vapors to avoid water solubility of the 3D structures in aqueous environments. The antimicrobial activity of the scaffolds was tested against Escherichia coli. The minimum inhibitory concentration (MIC) found for AgNPs-CS (chondroitin sulfate) scaffolds was ca. 6 ppm.
Highlights
The synergy among entities of a different nature that is found in nanocomposites will perform a key function in the progress of advanced functional materials in diverse fields, mainly in biomedical applications [1]
We report the green structured hierarchically in
Chondroitin sulfate and theirnanocomposites, use in an ointment particular of silver nanoparticles entrapped within activity chondroitin sulfate scaffolds with antibacterial properties and in vivo wound healing has been recently reported(AgNPs‐CS
Summary
The synergy among entities of a different nature that is found in nanocomposites will perform a key function in the progress of advanced functional materials in diverse fields, mainly in biomedical applications [1]. AgNPs synthesis in the presence of naturally occurring stabilizers such as Silver nanoparticles (AgNPs) have optical, antimicrobial and electrical properties that depend. AgNPs has been reported, with the etc., polymer acting both as using reducing agents as glucose, sodium borohydrate, ascorbic acid, by electrochemical amethods reducing stabilizing processes, agent by capping the AgNPs is asilver sulfated glycosaminoglycan viaand photochemical or by radiation [9]. A firstCS step, atoms (Ag0 ) are reduced (Figure that(Ag has ),attracted interest as a biocompatible biodegradable employed to silver1)ions which isgreat followed by agglomeration into and oligomeric clusters,polymer and ends in in pharmaceutical and biomedical devices. 3D nanocomposites to use capping agents to stabilize the AgNPs. composed of chondroitin multi‐walled carbon nanotubes (MWCNTs) forstabilizers nervous tissue.
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