Green Synthesis of Gold Nanoparticles using Adina Cordifolia Bark Extract and its Antimicrobial and in Vitro Anticancer Study

Abstract

In this study, green synthesis of gold nanoparticles were success fully synthesised by using <em>Adina cordifolia</em> plant bark aqueous extract which provides eco-friendly process, an environmentally benign, easy and proficient way for the synthesis of gold nanoparticles. The smaller size of gold nanoparticles have research on various dieses are very important. The green synthesized gold nanoparticles were characterized by UV-Visible spectroscopy, FT-IR, XRD, SEM, TEM and their antimicrobial activity was investigated. From UV-Visible spectrophotometer result was confirmed the formation of gold nanoparticles by color changed to ruby red color from pale yellow color indicates the reduction of Au<sup>3+</sup> ions to Au<sup>o</sup>. The antibacterial activity for the synthesized gold nanoparticles was confirmed by the antibacterial activity experiment against <em>Bacillus subtilis </em>and <em>Escherichia coli</em> by agar well method. The synthesized AuNPs was performed anticancer activity against MCF-7 breast cancer cell line. Compared to Adriamycin, Positive Control Compound AuNPs exhibited potent anticancer activity with the IC<sub>50</sub>. The green synthesized gold nanoparticles proved to be potential candidates for medical application antimicrobial and anticancer activity is highly essential.