Green synthesis of Copper Oxide Nanoparticles Decorated with Graphene oxide for Anticancer Activity and Catalytic Applications: An Advanced Study Approach

Abstract

Nanotechnology is a developing field with numerous implications for the drug delivery system. Nanoparticles, as haulers, greatly improve the capability of target-specific drug delivery and are thus used in the treatment of terrible diseases such as cancer, diabetes, and so on. The goal of this boom was to synthesise copper oxide nanoparticles (CuO-NPs) from Acalypha Indica leaf extract, which was then combined with graphene oxide (GO) to form GO-CuO nanocomposites. Second, observe the photocatalytic activity of CuO-NPs and GO-CuO nanocomposites in the decolorization of methylene blue dye, as well as its activity against HCT-116 human colon cancer cell lines. FTIR, UV-vis, X-ray powder diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDAX), X-ray Photoelectron Spectroscopy (XPS), and transmission electron microscopy (TEM) were used to characterise the synthesised nanocomposites. Photocatalytic studies revealed that synthesised nanocomposites degrade methylene blue dye with an efficiency of 83.20 percent and have a cytotoxic activity of 70% against HCT-116 Human colon cancer cell lines at 100 \(\mu g\)/ml. When compared to nanoparticles as a whole, GO-CuO nanocomposites exhibit significant activity against cancer cell lines as well as photocatalytic activity.