Green synthesis of Chloroxine-conjugated silver nanoflowers: Promising antimicrobial activity and in vivo cutaneous wound healing effects

Abstract

The aim of this research is to confect Chloroxine-conjugated AgNPs (COX-AgNPs), employing an eco-friendly method. The conjugation of antibiotics and antibacterial drugs with nanoparticles demonstrates better biological activity compared to free antibacterial and antibiotic molecules. Therefore, our groups employed Echinophora platyloba DC extract to prepared silver nanoparticles and subsequent conjugation of them to antibacterial drug Chloroxine. We employed the analytical techniques (UV–vis, DLS, zeta potential, SEM-EDX, FT-IR, XRD, and TEM) to investigate the composition, morphology, and size of the green synthesized AgNPs and COX-AgNPs. Our synthesized AgNPs displayed a remarkable antibacterial and antifungal activity against various microorganisms. The green synthesized AgNPs reported in this work is relatively smaller than some green synthesized AgNPs reported in the literature. Moreover, the efficacy of AgNPs was elevated by conjugating the antibacterial drug Chloroxine to them. Also, our finding indicated that COX-AgNPs have potential to accelerate wound healing, which refers to the antibacterial and antifungal activity of COX-AgNPs.