Green Synthesis of Barbituric Acid Derivative via Goldsmith Effluent Initiated Gold Nanoparticles and its Molecular Docking Study against Alzheimer Drug Target

Abstract

A convenient and efficient synthesis of 1,3-dimethyl-5-benzylidenebarbituric acid derivatives via gold nanoparticles is carried out. The gold nanoparticles were initiated from novel and low-cost goldsmith effluent source using green reducing agent D-glucose. By mediating autoclave at 121 ºC and 15 lb/cm2 pressure, these particles were further uniformly synthesized by using microwave radiation. The catalyst was analyzed using UV, IR and scanning electron microscopic techniques. Synthesized 1,3-dimethyl- 5-benzylidene-barbituric acid was assayed to study its inhibitory action against TAU protein.