Abstract
Green, eco-friendly method for synthesis of Au-Ag-In-rGO nanocomposite was developed using leaf extract of Piper pedicellatum C.DC. Its characterization was done by UV–Visible, FT-IR, XRD, XPS, EDX and TEM analysis. The α-glucosidase inhibitory assay revealed that the Au-Ag-In-rGO has excellent inhibitory potency compared to GO where Acarbose was used as positive control. The IC50 value was found 0.178±0.01 and 1.330±0.28µg/ml for Au-Ag-In-rGO and GO respectively. Cytotoxicity assay indicated that Au-Ag-In-rGO is more toxic than GO nanoparticles against PC3 prostate cancer cells compared to non-tumorigenic prostate epithelial cells, RWPE-1.
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