Abstract
Baloxavir marboxil is a novel anti-influenza drug with a unique mechanism of action that can effectively treat both type A and type B influenza. Key intermediate compound 7,8-difluoro-6,11-dihydrodibenz[b,e]thiophene-11-one is not only an important component of the chemical structure of baloxavir marboxil but also an essential intermediate in the synthetic route of the drug. However, conventional synthesis methods for key intermediate 7,8-difluoro-6,11-dihydrodibenz[b,e]thiophene-11-one usually utilize dangerous and harmful chemicals that can cause significant environmental pollution during large-scale production. This article proposes a new synthesis route for 7,8-difluoro-6,11-dihydrodibenz[b,e]thiophene-11-one to facilitate large-scale production while integrating the principles of green chemistry. This new route feature mild reaction conditions and simpler steps that result in an overall yield increase to 64.9%. More significantly, the new synthesis route reduces the use of hazardous chemicals, thus limiting the generation of hazardous waste during industrial production. This research offers significant potential for environmental pollution control.
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