Abstract
The purpose of this research is to develop the synthesis of chalcone through a green chemical approach that has the potential as an antibacterial. Chalcone synthesis was carried out using a grinding technique through a Claisen-Schmidt condensation reaction at room temperature for 30 minutes by grinding benzaldehyde (4-bromobenzaldehyde or 4- hydroxybenzaldehyde), 4'-methoxyacetophenone, and NaOH. The reaction product was purified by recrystallization through 96% ethanol. The purity of the compound was tested by TLC. Characterization of chalcones by FT IR, 1HNMR, 13C-NMR, and GC-MS showed that 4-hydroxy-4'-methoxy chalcone and 4-Bromo-4'-methoxy chalcone were formed. The antibacterial activity of Methoxy chalcone was determined in vitro by a disc diffusion test for grampositive and gram-negative bacteria. The test results showed that the second compound chalcone had weak activity against Staphylococcus aureus and was not active against Escherichia coli.
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