Abstract
AbstractA new, efficient and simple method was designed for the synthesis of novel β‐carbonyl ester derivatives by using the PPh3‐catalyzed one‐pot method, three‐component condensation from aryl amines, aryl aldehydes and dicarbonyl ester under solvent‐free conditions. The comparative results from syntheses under these conditions provide a very simple reaction procedure that produces excellent yields and high stereoselectivity, avoids column chromatographic separation and provides an easy aqueous work‐up compared with the conventional reaction. DFT calculations were utilized to confirm and understand the mechanism of the PPh3‐catalyzed Mannich reaction. Detailed analysis of the two‐reaction pathway and their energy difference proves the stereo‐selectivity effect of the Mannich reaction, favouring anti‐isomer formation.
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