Abstract
Poly-substituted double-thiazoles have been synthesized by the reaction of α-thiocyanate ketones, atomatic aldehydes and aminothiourea in H2O, underwenting Michael addition, the SN2 nucleophilic replace and the cyclized dehydration reaction sequently in this article. This seven-component reaction constructs two thiazole cycles, eight σ bonds in one step, maximizing synthetic efficiency and showing the superiority of atom economy, bonding economy and environmentally friendly. The structures of the products were determined by IR, 1H NMR. This reaction achieve green multi-component synthesis of heterocyclic compounds, which would be used in medicinal chemistry and chemical biology research areas.
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