Green Synthesis and Biological Study of Novel Cyclopenta[b]pyrrolizine: One‐Pot Multicomponent Reactions via Ag/Fe3O4@MWCNTs

Abstract

ABSTRACTIn this study, the cyclopenta[b]pyrrolizine was produced via using a nanocatalyst consisting of Ag/Fe3O4@MWCNTs in a multicomponent reaction that involved 2‐arylidenemalononitrile, ethyl 2‐amino‐4‐dioxo‐4‐arylbutanoates, alkyl bromides, and dimethyl acetylenedicarboxylate. The reaction was conducted in water at room temperature, resulting in the synthesis of new compounds. The synthesized compounds demonstrate antioxidant activity due to the occurrence of assessment procedures on its OH group. Moreover, an assessment was conducted on the antibacterial efficacy of recently synthesized pyridines using a disk diffusion method, employing two distinct strains of Gram‐negative bacteria. Notably, the tested compounds exhibited inhibitory effects on the growth of Gram‐positive bacteria as well.