Abstract
AbstractTrifluoromethylated molecules, as well as pyrazol‐3‐one derivatives, are found in a wide range of biologically active compounds. An highly facile, green and mild access to substituted 3‐(trifluoromethyl)‐4,5‐dihydro‐1H‐furo[2,3‐c]pyrazole derivatives by the cascade [3 + 2] Michael/Alkylation of unsaturated pyrazolones with α‐bromomalonate has been developed. The reactions can be performed in a easily available and environmentally benign solvent, and the substituted 3‐(trifluoromethyl)‐4,5‐dihydro‐1H‐furo[2,3‐c]pyrazole derivatives can be obtained in good to excellent yields by a simple purification step. The antifungal activities of these functional pyrazole derivatives were also evaluated and they showed high antifungal activity against Alternaria solani.
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