Abstract
Nanoparticles have emerged as a key player in modern medicine and involved in drug delivery, it can be manufactured using various approaches including chemical, physical, and biological methods. Nanoparticles are generally characterized by their size, morphology and surface charge using advanced microscopic techniques such as SEM and TEM. This study was aimed for synthesis and characterization of silver nanoparticle and to detect their antibacterial activity using Azadirachta indica (Neem) leaves extract. The results showed a visible change of colour after the addition of Neem leaf extract to AgNO3 solution to dark brown which indicates the formation of silver nanoparticle. UV spectrophotometer showed absorbance peak in range of 390-700 nm, the result revealed the highest peak showed by concentration 1 ml at 428.80 nm. SEM and XRD analysis were used to characterize synthesize silver nanoparticles. The antibacterial activity against Gram positive Staphylococcus aureus and Gram negative Escherichia coli and Klebsiella spp Microorganisms was carried out using disc diffusion method, the results showed that the highest activity was 14 mm against S. aureus. A. indica silver nanoparticles can be used as a new nano drug in formulation and delivery. The synthesized silver nanoparticles are extremely important in various areas of life and are widely used for the benefit of human being.
Highlights
Nanoparticles have unique chemical, physical and biological properties, and are used in various fields such as business, therapies, electronics, cosmetics; chemical catalysis and drug delivery [1]
Synthesis of Silver Nanoparticles For the synthesis of the silver nano particles, a certain volume of the Neem leaves extract (1, 2, 3, 4 and 5 ml) was added to the AgNO3 solution and the volume was adjusted to 10 ml with 1mM AgNO3 prepared as starting material for synthesis of silver nanoparticles in a test tubes, the reaction mixture in a test tubes were incubated at room temperature for 2 to 4 hours
Synthesis of Silver Nanoparticles Azadirachta indica leaves were used to produce silver nanoparticles and the reduction of silver ions into silver particles during exposure to the plant extract was followed by colour change
Summary
Nanoparticles have unique chemical, physical and biological properties, and are used in various fields such as business, therapies, electronics, cosmetics; chemical catalysis and drug delivery [1]. Metal nanoparticles have attracted a lot of attention in recent years due to their unique properties that differ from bulk materials These particles have gained importance in recent years due to their wide application in a number of processes such as agriculture, cosmetics, health care, delivery of drugs or genes, medical devices, biosensors and chemical catalysis [2]. AgNPs have the ability to work as therapies with diverse clinical and pharmacy properties It can be used in wide applications, including anti-cancer or bactericidal agents during surgery. In this way, green synthesis of AgNPs as new therapeutic powers will be important in various biomedical applications [3]. The present study reports the synthesis and characterization of silver nanoparticle from A. indica leaves extract and their antimicrobial activity
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