Abstract
Cefixime trihydrate (CFX) and cefuroxime axetil (CFU) are antibacterial drugs. They are widely used in the treatment of bacterial infection and recently in COVID-19 treatment. In this article, the two antibacterial drugs, CFX and CFU, were determined by a new simple, sensitive, effective, and green spectrophotometric method via reaction with silver nitrate (AgNO3). The reaction was based on reduction of AgNO3 by the cited drugs to silver nanoparticles (Ag-NPs) in the presence of polyvinylpyrrolidine (PVP) as stabilizing agent. Very intense surface plasmon resonance peaks were obtained at 435 nm for CFX and CFU that allow quantitative determination of the drugs. The calibration curves were linear with concentration ranges of 0.2-1.4 μg/mL and 0.3-2.1 μg/mL for CFX and CFU, respectively. Validation of the proposed method has been done according to ICH (International Conference of Harmonization) guidelines; the method was verified on the Green Analytical Procedure Index and Analytical Greenness metric approach (AGREE) in regard to its greenness and was found to be an excellent green alternative method. A very sensitive and green spectrophotometric method was developed for determination of CFX and CFU in pure and dosage form. The developed method not previously reported for simultaneous determination of CFX and CFU.
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