Abstract
Green Spectrofluorimetric Technique for the Determination of Vildagliptin Through Quenching Lanthanide Luminescence in Pure, Pharmaceutical Dosage Form and Spiked Plasma
Highlights
Vildagliptin (VIL) is known as (2S)-1-[2-[(3hydroxy-1 adamantlyl) amino] acetyl] pyrrolidine-2carbonitrile, Figure 1. It is used in the treatment of type II diabetes mellitus as it has a selective effect on inhibition of dipeptidyl peptidase-IV
Luminescence of lanthanide chelate was identified by large stock shift, narrow emission bands, and long fluorescence lifetimes
Acetonitrile, and isopropanol (Fisher chemical, United States), Fresh frozen human plasma samples were obtained from VACSIRA (Cairo, Egypt) and were kept frozen until use after gentle thawing in room temperature
Summary
Vildagliptin (VIL) is known as (2S)-1-[2-[(3hydroxy-1 adamantlyl) amino] acetyl] pyrrolidine-2carbonitrile, Figure 1. It is used in the treatment of type II diabetes mellitus as it has a selective effect on inhibition of dipeptidyl peptidase-IV. It could be taken alone or with other antidiabetic medications[1]. Luminescence of lanthanide chelate was identified by large stock shift, narrow emission bands, and long fluorescence lifetimes. They improve fluorometric detection of certain organic compounds[13] as fluoroquinolones[14], http://aprh.journals.ekb.eg/ 6
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