Green pseudo-multicomponent synthesis of some new spirocyclopropane derivatives via electro-catalyzed reaction.

Abstract

Due to the diverse applications of cyclopropane analogs in bioorganic, medicinal, and pharmaceutical chemistry, a clean and efficient procedure was established to synthesize spirocyclopropane via an electrochemical reaction which involves a sequence of Michael addition, halogenation, and intramolecular ring-closing reaction. In this study, an environmentally benign synthesis of spirocyclopropane was carried out through the condensation of indan-1,3-dione by aromatic aldehydes or 2-benzylidenemalononitrile derivatives. Constant current electrosynthesis was applied to a mixture of propanol containing sodium bromide as an electrolyte and a brominating agent at room temperature, respectively.