Green, Practical and Scalable Multicomponent Reaction for the Synthesis of Amides and Pyridazinones from Arenes Using L-Proline Functionalized Silicapropyl Modified Nanomagnetic as a Heterogeneous Bronsted Acid Catalyst

Abstract

A practical and scalable synthetic method for the synthesis of new amides and pyridazinones was established starting from the readily accessible materials as arenes, cyclic anhydrides, and 2-aminobenzimidazole or phenylhydrazine. This synthetic method includes a scalable reaction using L-proline functionalized propyl modified nanomagnetic in aqueous media without using any other harmful organic reagents or inorganic as AlCl3. The synthetic method enables to synthesize new amides and pyridazinone derivatives in manufacturing scale, with low reaction steps and high purity. The catalyst could easily be separated from the reaction mixture by using an external magnetic field and it was reusable and green.